Mediterranean cruises deliver ancient glories and modern delights, from Rome, Italy’s legendary Colosseum, and Dubrovnik, Croatia’s medieval walls to trend-setting Barcelona, Spain. Every day is filled with iconic cityscapes and landmarks, flaxen beaches, and remote coastal villages, fresh seafood paired with incredible wine. Spend the day on secluded Ionian isles on Greek cruises or explore Adriatic castles and palaces in Croatia. Our Mediterranean cruise itineraries are carefully curated to give you more options. Take a 7-day roundtrip cruise to Italy with a convenient weekend departure, or a longer voyage. We also include more overnights at the beginning and end of our itineraries, so you can spend an extra day in cities like Barcelona, Rome, and Athens, and use the ship as your hotel. Whether you choose to explore Greece, Italy, Croatia, or Spain, aA cruise to the Mediterranean is the best way to experience all that this breathtaking place has to offer. Welcome.

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Explore Mediterranean Cruise Ports & Regions

Collectors' Voyages

Collectors' Voyages are combined back-to-back itineraries to make your Mediterranean cruise a longer journey. Span continents and oceans and go to more seldom-seen destinations. Savor in more days at sea to unwind and more European cruise ports to discover. A Collectors' Voyage lets you unpack once and still see so much of the world. 

Featured Mediterranean Cruise Ports

A city view of Barcelona, Spain on a Mediterranean cruise

Barcelona, Spain

Explore architectural masterpieces, contemporary art scene and incredible cuisine in the Catalan capital.

visit the Acropolis in Athens, Greece on a Holland America Line Mediterranean Europe cruise

Athens, Greece

Tour ancient ruins on a cruise to the Mediterranean, including the Parthenon. Follow a day sightseeing with an open-air concert under the stars.

the colosseum in rome,italy

Civitavecchia (Rome), Italy

Rome is Italy’s beating heart, full of Renaissance cathedrals and piazzas begging for you to sit and sip espresso.

scene along the coast of montenegro

Kotor, Montenegro

Kotor is a maze of medieval beauty set on a bay with rolling mountains behind it. Walk along the Old City walls all the way up to Kotor’s fortress, where you’ll be treated to an overlook of red-orange rooftops.

View of Dubrovnik and the sea while while on an excursion from a Mediterranean cruise

Dubrovnik, Croatia

Experience Dubrovnik charms on a Croatia cruise, from its red-orange rooftops to vistas of the deep blue Adriatic.

gondolas on the canal in venice, italy

Venice, Italy

The city that floats on water and highlight of any Italy cruise, Venice needs no further introduction.

Santorini, Greece

Santorini, Greece

Santorini, the jewel in the crown of Greece's Cyclades, is best known as the island with the giant volcanic caldera at its heart.

Featured Mediterranean Cruise Shore Excursions

Eat, drink, and live like a local on Mediterranean cruise excursions and FOOD & WINE® tours. Visit a family-owned winery in Greece’s Oia to taste the rich flavors of this renowned region. Go shopping with a chef in a tucked-away charcutería in Barcelona. Or indulge in a night of traditional dancing and drinks. On European cruise lines the opportunities are endless.

Cruises to the Mediterranean

Niuew Statendam

Glide the Mediterranean aboard the sumptuous Nieuw Statendam. Cruise from Civitavecchia (Rome) or Amsterdam on voyages that go from 10 to 22 days.


Oosterdam, a Vista-class ship, recently emerged from dry dock with exciting updates—including completely refreshed suites and new lounge, dining and entertainment venues, such as Music Walk™, with Lincoln Center Stage, B.B. King’s Blues Club and Billboard Onboard.


Soak up every drop of the Mediterranean. Venture to the Greek isles and Adriatic coast and relish an immersive experience aboard this incredible Mediterranean cruise ship.

Add to Your Cruise to the Mediterranean

Booking flights online with Flight Ease by Holland America Line

Find Flights

Book flights that depart and arrive in time for Mediterranean cruises with Holland America Line Flight Ease®. Find low prices, loads of options, and enjoy flexibility and support should plans change.

Hotel room

Add a Hotel Package

Extend your cruise to the Mediterranean. Add a hotel package to your Mediterranean cruise and indulge in an unforgettable overnight departure or arrival city.

overland bus

Plan Ground Transportation

On European cruise lines there is a lot of ground to cover, so we make it easy to schedule transfers between the airport and ship. Arrange ground transportation ahead of time and breeze to and from your Mediterranean cruise.

Get Free Planning Help

Our consultants answer your questions, arrange hotel stays and find the best fares. Take advantage of this free service today.