Discover the Best Mediterranean Cruise Itinerary: Must-See Ports & Hidden Treasures

The perfect cruise, if planned well, offers a journey that combines the iconic with the unexpected. Whether you’re a first-time cruiser, foodie, history buff, or seasoned traveler eager to discover parts unknown, Holland America provides a variety of Mediterranean cruises to appeal to every interest with a curated blend of must-see cities and off-the-beaten-path destinations.

From the winding medieval lanes of Barcelona’s Gothic Quarter to the sun-drenched ruins of ancient Rome, we’re sharing the top Mediterranean cruise destinations—and exactly when to visit them for your best travel experience

The Mediterranean is widely known as a year-round destination, but the best time to cruise ultimately depends on your travel style:

• Shoulder season (April–May & September–November) offers weather that’s still warm but with less crowded attractions and better deals
• Summer (June–August) features lively ports and lovely beach days — great for families and sunseekers
• Winter cruising delivers some of the lowest prices and a relaxed pace, especially in Southern Europe

New to cruising? The Western Mediterranean offers an ideal introduction. Holland America’s 7- to 14-day itineraries typically set sail from popular cities such as Barcelona, Rome, or Athens, featuring worthy stops in cultural hubs like Florence, Marseille, and Naples. Don’t miss these must-see locales and excursions on your first foray into the Mediterranean:

• Explore Rome’s icons: Trevi Fountain, the Spanish Steps, the Colosseum, and more on a hop-on, hop-off tour
• Tour the architectural wonders of Antoni Gaudí in Barcelona
• Explore the coastal beauty and ancient history of Marseille

For a well-rounded Western Mediterranean cruises, consider:

11-Day Western Mediterranean: Spain, Italy & France

14-Day Italy, French Riviera & Spain Collectors’ Voyage

Looking to cruise beyond the typical tourist routes? Set your sights on the Eastern Mediterranean—where every port offers a rich tapestry of history, culture, and breathtaking scenery. From the storied Greek Isles to the ancient ruins of Ephesus in Turkey, this region offers deep cultural immersion for travelers seeking more than just the usual stops.

• Explore Kotor, Montenegro—a stunning medieval town tucked between fjord-like mountains
• Visit Kročula, Croatia—a walled island some think might be Marco Polo’s birthplace
• Relax on the Aegean coast in Cesme & Kusadasi, Turkey
• Discover panoramic views from the clifftop citadel in Bonifacio, Corsica

10-Day Adriatic Allure: Croatia, Greek Isles & Istanbul
21-Day Croatia, Greece, Istanbul & Egypt Collectors’ Voyage

For discerning epicureans—or really, anyone who just loves good food—the Mediterranean serves up some must-sample delicacies. Explore the rich flavors of Italy, Greece, and Spain, each country proudly sharing its culinary standouts and quality wines.

Leave space for exploration and your next great taste on a selection of Mediterranean shore excursions that are sure to pass the ultimate taste test:

• Market tours and cooking classes in Barcelona or visit the bustling market, La Bouqueria
• Wine tastings in Santorini, known for its volcanic terrain
• Olive oil parings in Corfu, or creating handmade pasta in the Etruscan countryside

14-Day Greece, Italy & French Riviera Collectors’ Voyage

18-Day Spain, Italy & Greek Isles with HISTORY™ Channel

Travel through time aboard a Holland America cruise, especially in partnership with the HISTORY™ Channel. These itineraries spotlight some of the Mediterranean’s most legendary sites:

7-Day Western Mediterranean with HISTORY™ Channel

7-Day Mediterranean: Greek Isles with HISTORY™ Channel

Plus, with access to 175+ UNESCO World Heritage Sites, you can channel your inner archaeologist or historian.

If you’re cruising with energetic kids, jaded teenagers, or thrilled-to-be-included grandparents, our Mediterranean cruises cater to all age groups. With spacious staterooms, family-friendly excursions, and mid-sized ships, Holland America is a wonderful fit for multi-generational travel.

• Explore the epic ruins of Pompeii
• Step into a medieval walled town laden with castles and knights’ tales in Rhodes
• Explore L’Aquárium de Barcelona or the cliffs at The Calanques of Marseilles—ideal spots for animal and nature lovers
• Unwind with beach time in Crete

Astronomy lovers and celestial seekers, mark your calendars! Holland America offers opportunities to align withonce-in-a-lifetime sky events while off the coast of the Mediterranean, enjoying unobstructed views.

2026 13-Day Mediterranean Solar Eclipse with Barcelona Overnight

2027 14-Day Solar Eclipse & Astronomical Discovery

Whether you’re aiming to tick off the Mediterranean’s iconic ports from your travel wish list or eager to discover new hidden gems, Holland America offers a diverse lineup of sailings to suit every traveler—from first-time adventurers to seasoned cruisers with more passport stamps than they can count.

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