Visit Rome’s legendary Colosseum. Shop Monaco’s glamorous boutiques. Sample succulent tapas in Barcelona. Walk the medieval wall that guards Dubrovnik’s charms. Unwind under a canopy of stars. 


All of our cruise itineraries offer just the right balance of action-packed days in port with relaxing days at sea, plus extended hours and overnight stays in select cities. We also include more overnights at the beginning and end of our cruises, so you can spend an extra day exploring cities like Barcelona, Venice and Rome, and use the ship as your hotel. Whether you’re making your maiden voyage in the Mediterranean and want to see its more iconic sights or you’ve traveled here before and are hoping to experience some of its seldom-visited destinations, Holland America Line has the Mediterranean cruise vacation you’ve been waiting for.

Mediterranean Ports & Regions

A Magical Night in Venice

Take a moonlit gondola ride through fabled waterways. Dine on freshly made pasta at a charming bistro. Enjoy a leisurely winery tour. Attend a classical concert in a Renaissance-era church and more—on an overnight in Venice.

Beautiful Barcelona

Las Ramblas, with its unrivalled people-watching; the curving, sinuous lines of Gaudí’s architectural masterpieces; the vibrant contemporary art scene and cuisine; make this Catalan capital a must-see for sophisticated travelers.

Charming Dubrovnik

Perched high above the Adriatic Sea, Dubrovnik is walled medieval city of cobblestone lanes and red terra cotta roofs, Explore St. Blaise Church, the Sponza Palace, the Rector’s Palace and other gems. Sip the region’s finest wines in Komaji.

italy's West Coast

A treasure trove of iconic sites, Italy’s west coast also has some remarkable hidden gems. AFAR deputy editor, Jenn Flowers, has recommendations for several seldom-seen “must see” places.

Ships serving the Mediterranean

Nieuw Statendam

Our new Pinnacle-class ship, Nieuw Statendam debuts in Europe this fall with Mediterranean cruises of 10 to 22 days, sailing from Civitavecchia (Rome) or Amsterdam. Relax on a Santorini beach, enjoy tapas on Las Ramblas and more.


Based in Civitavecchia (Rome), Koningsdam, our first Pinnacle-class ship, sails roundtrip Mediterranean itineraries of 9 to 25 days, April through October. Explore ancient glories, Renaissance treasures and iconic European cities.


With home ports in Rotterdam, Amsterdam and Civitavecchia (Rome), Rotterdam offers 14- and 28-day cruises in October, when visitors are few. Visit the Eiffel Tour, Rome’s Colosseum, the canals of Venice and Jerusalem’s Old City.


With April through October cruises, ranging from 7 to 31 days, and departing from Civitavecchia (Rome), Venice, Barcelona and Amsterdam, Veendam offers a wide array of vacation experiences in the Mediterranean and beyond.


Choose a 12- or 24-day Mediterranean cruise, departing from Civitavecchia (Rome) or Venice, in May or June. Unwind in the Greek isles, walk Normandy’s historic beaches, tour Dubrovnik’s walled Old Town and explore Pompeii.

Nieuw Amsterdam

With home ports in Venice, Barcelona and Civitavecchia (Rome), Nieuw Amsterdam sails 12- and 24-day Mediterranean cruises, April through October. Experience Istanbul’s Blue Mosque, Gaudí’s Parc Güell and the canals of Venice.

Best Mediterranean Shore Excursions

Mediterranean Cruise Itineraries

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12-day Mediterranean Romance

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10-day Mediterranean Dream

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7-day Adriatic & Ionian Gems

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